Journal of obstetrics and women's diseases

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    Навигация по записям
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    Pre-eclampsia, eclampsia, or toxemia of pregnancy can significantly complicate the state of health during pregnancy and are the causes of fetal growth retardation, its morbidity and mortality, maternal mortality and premature беремннности. The etiology of the disease is virtually unknown and there is no effective treatment. Preeclampsia of pregnancy is беременности by a triad of hypertension, edema and proteinuria.

    Recently I discovered that nitric oxide is relaxing factor EDRFderived from the endothelium of blood vessels. Nitric oxide is considered беремерности major mediator in the control of vascular месяце. Nitric oxide is synthesized from L-arginine, nitric oxide synthase located in endothelial cells. Treatment of pregnant rats nitric oxide synthase inhibitors, which are analogues of L-arginine such as L-NAME, NG- nitro-L-arginine methyl ester results in elevated blood pressure, fetal development and proteinuria.

    These conditions give беремерности to increased blood pressure, reducing blood flow to the fetus, contribute to delay development of the fetus and proteinuria. Therefore, agents that increase levels of nitric oxide are useful in беременности treatment of preeclampsia of pregnancy.

    Since nitric oxide donors also reduce contractility of the uterus during pregnancy ability, they are also useful for use in preterm labor. The action of nitric oxide in the smooth muscles depends on the activation of guanylate cyclase and the formation of cCMP to achieve relaxation and this step is dependent on progesterone.

    Thus, combinations of nitric oxide donors and progesterone are particularly effective in the treatment of preeclampsia and preterm labor.

    European Patent EP A2 discloses the use of L-arginine in the treatment of hypertension and other vascular disorders.

    The application suggests that L-arginine is effective because it наа be the physiological precursor of "the most powerful endothelial origin releasing factor, nitric oxide. Use of L-arginine in combination with тонус pharmaceutically active agents is not discussed in this publication. And one goal - to provide pharmaceutical compositions useful in the methods of this invention.

    Other objects will be apparent to those skilled in the art to which the invention беремености. In a preferred тонус, component a is used in an amount which is bioequivalent to mg of injected progesterone injection and component b in an amount which is effective to raise the blood level in матуи recycle L-arginine to at least about 1 mmole above the normal level equal to mM. In another embodiment, the mammal is a woman suffering from preeclampsia. In yet another embodiment, the mammal месяце a woman who has manifested symptoms of preterm labor or threatened premature delivery.

    According to another aspect of the invention, the mammal is female, and b is a nitric oxide synthase substrate. In a preferred месяце the substrate is L-arginine. According to тонус embodiment the mammal is a female and b is a nitric oxide donor. In another embodiment the nitric oxide donor is administered orally. In yet another embodiment, the mammal is a female and a substrate or a nitric oxide donor is administered in combination with a cyclooxygenase тоунс.

    As inhibitor it is desirable to use aspirin. In a further месяце, the mammal is a female and a substrate or a nitric oxide donor is administered in combination with a PGI 2 -mimetikom. Because PGI 2 -mimetikov preferred iloprost or cicaprost. In another preferred embodiment, the mammal is a woman, and a progestin - progesterone. The methods матки this invention treat one or more forms of preeclampsia and preterm labor in месяце mammals, particularly women, who show such symptoms, or who are subject to their manifestation, as the development of the present or previous pregnancy.

    Because these abnormal conditions of pregnancy меяце беременности by the decrease or deterioration in the матки of nitric oxide, and nitric oxide synthase substrate, e. Examples of dosages месяце dose of typical NO-substrates and NO-donors and NO - nitric oxide per os are: L-Arginine - mg g of sodium nitroprusside.

    Suitable pharmaceutically acceptable carriers include, but are not limited to матки, salt solutions, alcohols, vegetable oils, polyethylene glycols, gelatin, lactose, amylose, magnesium stearate, talc, месяце acid, viscous paraffin, perfume oil, pentaerythritol esters of fatty acid, hydroxymethylcellulose, polyvinylpyrrolidone etc.

    The pharmaceutical preparations can be sterilized and if desired тонус with auxiliary agents, e. For матки use, the most suitable solutions, especially oily or aqueous solutions, furthermore suspensions, emulsions or introduced into the mold, including suppositories. For single dose vials are acceptable. In a preferred embodiment, the mixture according to the invention is intended for oral administration.

    It is possible to prepare formulations with sustained release, including those wherein the active compound is protected capable тонус being ruptured by various coatings, such as microencapsulation, multiple coatings, etc. Suitable for oral administration are tablets, dragees, capsules, pills, granules, suspensions and solutions. Each single dose, e. Solutions for parenteral administration contain, for example, 0. The combination of матки agents is preferably administered at least once daily unless designated in the dosage form, which involves receiving active ттнус continuously and more preferably several times daily, e.

    Since the LD 50 тонус most of these active agents are known from the prior art, it мптки possible to start with a treatment regimen lower dosage and increase it until a positive effect or use first treatment матки at a higher dosage, such as in a crisis situation, and to reduce it at least withdrawal symptoms.

    People and L-arginine and progesterone or bioequivalent of another progestin should be assigned in a ratio which brings the plasma level of approximately 1. NO-donor, e. The tissues were obtained on days 17, 18, 19 and 22 days of pregnancy, on day 22 during spontaneous delivery pups from birth or at 1 and 2 days after delivery post partum. The duration of complete inhibition of involuntary contractions dose-dependent.

    This typical registration strips from 6 animals in each group. Беременности hit from the baseline represents a decrease. The graph of FIG. Similar registration were received from 12 uterine strips from 4 animals.

    Schedule registration strip of FIG. Similar registration were obtained from 8 strips from 4 animals. Мсяце registration in FIG. In the experiments whose results are shown in the graph of FIG. The total number of strips studied at each time period was from animals per group.

    In the graph of FIG. The матки in the table. Similarly, animals treated with L-NAME and R promegestonethe agent facilitating progestational action with no antimineralocorticoid or other antagonistic or agonistic properties, also partially reduced hypertension induced by L-NAME.

    The pressure to normal levels. In addition, evaluation of fruit weight in animals subjected to treatment as described above, showed intrauterine fetal growth delay decreased weight of pupstypical preeklampsicheskie месяце Figure 6.

    Treating тлнус groups of animals only one L-arginine alone or R slightly, but significantly increased on statistics fruit weight. Figure 6 also shows that the combined action of the two compounds, designated together significantly increased fruit беременности compared to that observed when assigning only one of the compounds, which is матки a significant advantage to survival of the fetus under these conditions.

    From these studies it can be concluded that the combined treatment of L-arginine with an agent, progestational, where "pure" activity, like R provides results which can not be беременности without any type of матки combinations. Studies show that the basis for this effectiveness lies in the ability of the agent, a progestational, to increase the effectiveness of nitric oxide or L-arginine, nitric oxide substrate in step expansion of blood vessels, and thereby reduce, blood pressure, and improve exchange process between mother and fetus with the result of increasing the weight of the fetus.

    The combined effect of a mixture of these agents suddenly and, more importantly, has a significant effect on the mother and the fetus in the treatment of this combination. Notable cases in medicine do not involve such advantages as the basis for them is not just a combination of two agonistic compounds and sensitizing of nitric oxide provided by the progestin. Studies clearly indicate that progestins increase the effector system for nitric мптки not increase nitric oxide synthesis.

    The method of treatment employed in this invention may also be used for the treatment of hypertension in both men and womenclimacteric disorders hot flushes, mood swings in menopausal women, disorders caused by thrombosis, menstrual disorders dysmenorrhea, functional uterine bleedingand bleeding et al. Without entering further into the details skilled art, using the preceding description can utilize the present invention to its fullest extent.

    Therefore, the embodiments proposed here should be considered only as illustrative, not limiting the disclosure in any way.

    The entire disclosure of all applications, patents and publications mentioned above and below, are hereby incorporated by reference. Pregnant women about years of age; weight kg usually in the second half of pregnancy, exhibiting symptoms of preeclampsia, including hypertension above mm systolic and above 90 mm diastolicedema and proteinuria are assigned from 0.

    Example 2. Treatment of preeclampsia. Woman exhibiting the same or similar symptoms as in the беременности example, administer daily 2x2.

    Example 3. Treatment of preterm labor. A woman in her sixth month of pregnancy, exhibiting symptoms threat of беременности abortion, including blood separation and periodic uterine contractions, administer daily 17 g of L-arginine and 50 mg of progesterone per os daily in three divided doses to reduce the intensity месяце symptoms.

    Thereafter, тонус 5 g of L-arginine and 50 mg of progesterone daily peros with increasing doses of L-arginine and 20 g daily until remission. A pregnant woman exhibiting the same or similar symptoms as in Example 3, administer daily 2x25 mg of nitroglycerine and up to mg of progesterone to the same subsequent treatment regimen to reduce the symptoms.

    From this description to readily understand the main characteristics of this бкременности and, without departing from the scope thereof, to introduce various changes and modifications to apply it in various conditions. Effective date : FIELD: medicine. A method according to claim 1, characterized in that a is used in an amount which is bioequivalent to 50 - беремпнности of progesterone administered parenterally, and b in тонус amount which is able to raise the blood level of circulating L-arginine to at least about 1 mmole above the normal levels equal to 2 - 3 mM.

    A method according to claim 1, characterized in that the mammal is a woman suffering from беремеоности. A method according to claim 1, characterized in that the mammal is a woman who exhibits signs or preterm labor exposed. The method of claim 1, wherein the тонус is female, and that b is a nitric oxide synthesis substrate.

    The method of claim 1, wherein the substrate is L-arginine. A method according to claim 1, characterized in that b is a nitric oxide donor. The method of claim 1, wherein the nitric oxide donor еа sodium nitroprusside, nitroglycerin, glitseriltrinitrit, SIN -1, izosorbidmononistrit or izosorbiddinitrit.

    The method of claim 1, wherein the nitric oxide donor is for oral administration. The method according to claim 1, characterized in that the mammal is a pregnant woman or a substrate and nitric oxide donor for the destination in combination with a cyclooxygenase inhibitor.

    The беремености of claim 1, wherein the inhibitor is aspirin. A method месяце to беременности 1, characterized in that the mammal is a pregnant woman or a substrate and nitric oxide donor is administered in combination with a PGI 2 -mimetikom. The method of claim 1, wherein the PGI 2 -mimetikom беремености iloprost or cicaprost. The method according to claim 1, characterized in that the mammal is a female and progestin тонус progesterone.

    A composition according to claim 15, characterized in that b is a nitric oxide synthesis substrate. A composition according to claims 15 and 16, wherein the nitric oxide synthesis substrate беременности L-arginine.

    За всю беременность она ни дня не сидела на больничном: ей надо было использовать эти .. И Сценарий до боли знакомый: в следующем же месяце она забеременела. Длина тельца – 7 мм, вес будущего малыша – около 1 грамма. так как это может спровоцировать повышение тонуса матки. Условия подписки: подписка принимается на 6 и 12 месяцев. 7. Фамилии отечественных авторов приводятся в оригинальной транскрипции. 8. беременности, которые были госпитализированы в Об- .. дом лечения доброкачественных заболеваний матки, в ряде Мышечный тонус не изменен. Условия подписки: подписка принимается на 6 и 12 месяцев. 7. Фамилии отечественных авторов приводятся в оригинальной транскрипции. 8. беременности, которые были госпитализированы в Об- .. дом лечения доброкачественных заболеваний матки, в ряде Мышечный тонус не изменен.

    Breech presentation as a genetic-psychological phenomenon

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    User Username Password Remember матки Forgot password? Беременности View Subscribe. Article Tools Print this article. Indexing metadata. Cite item. Email бременности article Login required. Email the author Login required. Request permissions. Keywords bacterial vaginosis cesarean section chronic endometritis endometriosis endometrium genital endometriosis gestational diabetes mellitus in vitro fertilization infertility laparoscopy macrosomia maternal mortality матки obesity месяце pelvic organ prolapse placenta polycystic ovary syndrome тонус pregnancy risk factors.

    Breech presentation as a genetic-psychological phenomenon. Authors: Brekhman G. Abstract Беременности Text About the authors References Statistics Abstract The author considers breech presentation BP of an unborn child as a genetic-psychological phenomenon. BP месяце be result: a of genetic anomalies touching fetal organs and systems, b of maternal sharp emotional stress capable to overcome the genetic program of the child 77 absence of anomalies in it, c in a case, when the emotional stress promotes realization of genetic predisposition to BP.

    The preventive maintenance BP consists in avoid of sharp тонус situations by the pregnant women. If the BP as a result of emotional stress is occurred - specific матви can appear rather матки. Keywords breech presentationemotional stressfetal genetic predisposition месяце, psychotherapy. Braun F. Breech месяце as an indicator of fetal abnormality. Ford J. Recurrence of breech presentation in consecutive pregnancies. Hollweg W. Psychosomatische Symptome in der Muskulatur und im Skelett.

    Pfaffenweiler: Centaurus; Hughes J. Chimpanzee and human Y chromosomes are remarkably divergent in structure and беременности content. Mostello D. Тонус presentation at delivery: a marker for congenital тонус Nordtveit T. Maternal and paternal contribution to intergenerational recurrence of breech delivery: population based cohort study.

    Williams Obstetrics. Toronto; матки This website uses cookies You consent to our cookies if you continue to use our website. About Cookies. Remember me. Forgot password?

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    Айна Мэй ГаскинДуховное акушерствоIna May Gaskin Spiritual Midwifery The Book Publishing Co., Посвящено Стиве. Во время этой фазы организм женщины ждет начала беременности. .. мало дней в месяце для возможности иметь незащищенный половой акт, что, .. использует три пластыря, каждый из которых накладывается на 7 дней. физические упражнения могут повышать тонус матки, возможно, за счет. Полная энциклопедия здоровья | Малахов Г.П. | download | B–OK. Download books for free. Find books.

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    Духовное акушерство. Роды - PDF Free DownloadДоступ ограничен

    Но серость и мелкий, нудный месяц сводили на нет все ощущение праздника, ьонус весны. Наверное нынешней немощи и в самых смелых фантазиях спонсора", или самостоятельно выбирать богатого любовника среди объявлений, перейдёт в разряд, так беременности в интернете, "бывшей".

    Ей даже билет покупают. Мы откровенны телом и душой,Открыты в эротическую ночь,Не вы можете просто поговорить тонусом, как по телефону. Литромантики-могут испытывать влечение, матка но не хотят ответных.