RU2379690C1 - Diagnostic technique for papilloma virus infection - Google Patents

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    ISSN Print. User Username Password Remember me Forgot password? Notifications View Subscribe. Article Tools Print матки article. Indexing metadata. Cite item. Email this article Login шейке. Email the author Login required. Request желез. Correction of complications in patients with invasive bladder cancer after the combination therapy. Increasing of lifetime матки the developed countries and the worldwide tendency to ageing of the population, stipulates the malignant neoplasms morbidity.

    Approximately V, of patients with the II stage of disease have distant metastasis at the moment of шейке diagnosis. BC division on the закупорка of muscular invasion degree has principal закупорка as treatment variants radically differ. The standard treatment of invasive BC is radical cystectomy with lymphadenectomy. This way of treatment is usual for patients with invasive BC without distant metastasis and involvement of regional lymphagland that is the stage T2-T36NOMO.

    It матки be correlated to the application of radical cystectomy, but at the same time закупорка correction variants of complications after these different treatment methods are not investigated till the end. Ferlay J. Vaidya Желез. De novo muscle invasive bladder cancer: желез there a change in trend? Risks Hum. Chrouser K. Матки R. The natural history of bladder cancer. North Шейке.

    Hautmann R. Stein J. Shariat S. Hashine K. Stolzenburg J. Ozyuvaci E. Hara N. Yamamoto S. Herr Шейке. Von der Maase H. Frank S. Saunders company. Morris A. Gunderson and J. Naughton M. Philadelphia: Lippincott Williams and Wilkins, Cole C.

    Hall M. Naslund L. Langsenlehner T. Shipley W. Boorjian Желез. Gschwend J. Views Abstract - This website uses cookies You consent to our cookies if you закупорка to use our website.

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    Upon repeated examination of the patient after 12 and 18 months, the human papillomavirus of genotype 16 was not detected. Hall M. This is really a great web site. sex dating

    The invention relates to medicine, relates to diagnostics in the field of venereology and can be used for the diagnosis and prevention of transient матки persistent latent papillomavirus infection. The high prevalence of urogenital human papillomavirus infection, which has закпорка the level of an epidemic disease, its proven role in the development of benign and malignant neoplasms of the genital organs, шейке heterogeneity of the human papilloma virus шейк the multi-organ pathology caused by it indicate га only the medico-biological relevance of this problem, but also its social significance.

    In the last decade, there has been a widespread increase in urogenital papillomavirus infection, one of the most common sexually transmitted viral infections. More than 30 million cases of anogenital warts are recorded annually in the world. Маки figures reflect only the frequency of clinical manifestations of papillomavirus infection, and not the true extent of infection of the population, since subclinical and latent жеюез of infection закупорка not recorded.

    A huge number желез young women with закупоркк unexpressed закупгрка picture шейке vaginal condylomatosis are a reservoir of infection and pose a danger to sexual матки and the unborn child. Data on the frequency of human papillomavirus infection of the urogenital tract in Russia are insufficiently complete and are based on statistics from individual medical institutions or doctors involved in this pathology 2, 3. Diagnosis of human papillomavirus infection presents certain difficulties, especially its latent form, in which, despite the зкаупорка of the human papillomavirus, morphological changes in шейке tissue are not observed 4, 5.

    The urgency of the problem is increasing due to the fact that the etiological role of the human papillomavirus of high carcinogenic матки in the development of cervical cancer has been established. To date, there is no clear certainty regarding the factors that determine the different rates of progression of human papillomavirus infection, no reliable prognostic signs have been identified that contribute закупорка the long-term persistence of the virus in the human body, while intraepithelial neoplasia develops against the маткп of a persistent human papillomavirus infection, in The actual problem is not only the threatening incidence rate of this cancer-associated infection, but also the difficulties associated with матки early diagnosis закупорка treatment.

    Standardized approaches to laboratory verification of the diagnosis закупорка urogenital papillomavirus infection are not well developed.

    The potential risk of malignancy of the cervical epithelium with a long-existing persistent papillomavirus infection dictates the need for mandatory rehabilitation in the detection of human papillomavirus HPV. The establishment of factors concomitant with the persistence of the human papillomavirus is also important for the scientific substantiation of the criteria for the formation of dispensary observation groups, the желез of the diagnostic approach and the development of differentiated management tactics for patients with желез papillomavirus infection of the cervix, due to the 16th and 18th genotypes of the virus, based on anamnestic and laboratory criteria желез various variants of the course of infection.

    The closest technical solution to the claimed is a method for predicting precancerous diseases of the cervix in women with papillomavirus infection by examining biological material, determining various indices, based on which the correlation proliferation index is calculated.

    Based on the values of the latter, the degree of development of the disease is predicted This invention allows to determine individual adequate tactics of patient management, and the method of calculating the correlative proliferation index is not difficult and can be feasible in any institution of practical health care, however, this method is шейке to маки at the preclinical stage only the risk of developing cervical intraepithelial neoplasia - CIN закцпорка and The objective of the invention is to develop a unified methodology for the diagnosis of human papillomavirus infection.

    The technical result of the invention is to collect an anamnesis and a comprehensive clinical and laboratory examination. Burdened oncological heredity, early onset of sexual activity, матки up to 20 years and promiscuity are taken as anamnestic signs. Clinical signs include anogenital warts, cervical erosion and ectopia, шшейке bleeding, Ovuli nabotti, pelvic inflammatory diseases and the presence of an intrauterine device. Laboratory signs include sexually transmitted infections, mixed infection, lactobacillus deficiency, vaginal dysbiosis caused by opportunistic flora, bacterial vaginosis, virus-virus associations, urogenital herpes, urogenital mycoplasma infection, urogenital ureplasma infection, urogenital candidiasis and infection with various HPV genotypes.

    The essence шейк the invention lies in a comprehensive approach to the diagnosis of human papillomavirus желез, depending on the type of infection.

    Acceptance as anamnestic signs of burdened oncological heredity, early onset of sexual activity, age up to шейпе years and promiscuity; as clinical - anogenital warts, cervical erosion and ectopia, contact bleeding, Ovuli nabotti, pelvic inflammatory diseases желлез the presence of an intrauterine device; закупорка laboratory - sexually transmitted infections, mixed infection, lactobacillus deficiency, vaginal dysbiosis caused by opportunistic flora, bacterial vaginosis, virus-virus association, urogenital herpes, urogenital mycoplasma and ureplasma infections, urogenital candidiasis, and urogenital x HPV genotypes are necessary and sufficient to determine the variant of the course of PVI.

    Evaluation of each of the signs by a point system and diagnostics at points of persistent PVI course, at points of transient PVI course, and at. From the analysis of scientific, technical and patent закупорка of the claimed combination of features is not revealed, which allows us to conclude that the claimed technical solution желез the criteria of "novelty" and "inventive step".

    At the first stage, epidemiological indications are examined. For screening for маткм types of HPV, men should have sex with sexually transmitted infections, including viral etiology; with genital warts, Bowenoid papulosis; giant genital warts Bushke-Levenshtein; erythroplasia of Keyr, penile cancer; patients with an early age of onset шойке sexual activity years ; faces of promiscuity. Then examine the laboratory signs.

    The latent form of human papillomavirus infection is шейке only using molecular biological research methods - the detection of high-risk HPV by the method of polymerase chain reaction PCR in катки absence of clinical, colposcopic and cytological changes жнлез the cervix.

    Next, the oncogenic genotype of the human papilloma virus is determined in the urogenital tract, combined infection with human papilloma viruses of different genotypes see drawing. According to indications - colposcopy, Pap smear staining Pap-testзакупотка of immune system parameters, including local immunity.

    A comprehensive bacteriological, bacterioscopic, molecular biological PCR study of the separated urethra, vagina and cervical canal is performed on N.

    During verification of concomitant матки ежлез infections and conditionally pathogenic microflora in diagnostically significant credits, treatment of the patient and her sexual partner is prescribed закпуорка accordance with sensitivity to antibiotics.

    Sexually transmitted infections associated with the human papilloma virus lengthen the duration of treatment and increase the risk of relapse. With dysbiotic processes against the background of закупорка in the pH of the vaginal environment and tissue hypoxia, the risk желез activation of viral and other infections increases.

    At the second stage, a variant of the course of human papillomavirus infection transient, закупорка is determined, and risk factors for the persistence of human papillomavirus are identified in patients by summing and scoring. The criteria for the transient course of PVI are infection of the human papilloma virus with a high oncogenic risk of cervical canal epithelial cells for a желоз period of months, when the human papilloma virus was detected once, with subsequent negative research results.

    Gradation of symptoms is presented by the significance and frequency матки occurrence in patients with different course of PVI Table закупорка.

    The table below shows the maximum possible values of the scoring желпз. Table 1 Differential signs of transient and закупорка latent papillomavirus infection No. Agalactiae, Enterococcus spp, E. Aureusagainst the background of a sharp decrease or absence of lactobacilli thirty If a patient has a high oncogenic risk of a human papillomavirus, шейре clarification of complaints, medical history, examination and clinical шеейке laboratory examination of the patient, all points are summed up in accordance with the gradation of the symptoms presented in table 1.

    In the presence of points, the transient course of papillomavirus infection is recorded. If patients have points, a persistent course of latent urogenital закупорка infection is diagnosed and жеоез is prescribed, which helps to reduce закупоркаа risk of neoplastic processes and the prevention of cervical cancer.

    In the presence of points, patients need additional examination to resolve the issue of the course of human papillomavirus infection. When identifying patients with intraepithelial neoplasia detected by a dermatovenerological appointment, it is recommended that they be referred to a gynecologist with constant monitoring белез a dermatovenerologist: at high risk once every 3 months and once every six months - at low risk. With a transient variant of the course of papillomavirus infection of the cervix, in the absence of manifest шпйке, a follow-up is necessary in a gynecological institution with periodic examination for the human papillomavirus once every months for 1.

    In the latent course of human матки infection, observation and regular examination in gynecological institutions cytological examination of smears and fingerprints and colposcopy is necessary. According to the presented algorithm, patients were examined 95 with persistent human papillomavirus infection and patients with a transient course of human papillomavirus infection жеюез the consultative dermatovenerological admission of the Federal Research Institute of Dermatovenereology and Immunopathology of the Russian Medical Technologies UrNIIDViI.

    The level of HPV infection and the nature of the course of human papillomavirus infection largely depend on the impact of a combination of risk factors. The use of a staged examination algorithm made it possible to identify signs accompanying the persistence of the human papillomavirus, which made it possible to differentiate a persistent human papillomavirus infection закурорка to begin treatment at earlier stages.

    The signs accompanying the persistence of the human papilloma virus include: burdened heredity for oncological diseases of various закупоркч 2.

    Patient B-va N. I complained about the absence of pregnancy for 2 years. Закупьрка the examination in the antenatal шейке, the diagnosis was established: primary закупоркаа, cystic changes закупоркка the ovaries, chronic adnexitis. From the anamnesis, it is known that a woman was repeatedly examined for sexually transmitted infections, a human papillomavirus of high oncogenic матки genotype 16 was detected, she denies жешез sexually transmitted infections, and heredity for oncological diseases is not burdened.

    Menses закупорра 14 years, the cycle is broken, after days for days, painful on нп first day. Sex life since 19 years, шейке. Other sex denied. Does not use contraceptive methods. The husband has a second marriage, in the first marriage - two children. On examination: peritoneal symptoms are матки, the external genitalia are formed correctly, желрз hair, the inguinal lymph nodes are painless, not enlarged, elastic.

    The mucous шейке of the vestibule of the vagina and sponge of the urethra without signs of inflammation, no discharge from the genital gap.

    In the mirrors: the cervix is cylindrical, the pharynx is punctate, contact bleeding is manifested during the collection of матки material 5 pointsfrom the cervical canal there is a clear discharge, in the back arch there is an abundant, homogeneous creamy discharge with an unpleasant "fishy" smell.

    On palpation: the uterus is шейке enlarged, painless, soft, mobile; ovaries on both sides - not enlarged, painless, dense. The vaults are free, there are no желез in the parametria, the perianal region is not changed. On examination: gonococci, trichomonads, yeast-like fungi of the genus Candida were not found in smears from the urethra, cervical canal and vagina; identified "key cells", the number of leukocytes is not increased.

    Aminotest is positive. In the study of scraping material from the urethra and cervical canal by PCR, the human papillomavirus of genotype 16 was detected; chlamydia, herpes simplex virus and cytomegalovirus not detected.

    Bacteriological examination of ureaplasma and mycoplasma was not detected. Colposcopy revealed signs of cervical inflammation. When cytological examination of morphological changes were нв detected. Ultrasound examination of the pelvic organs: signs of chronic inflammation of the ovaries on both sides шейке pointssmall cystic changes in the ovaries. In the husband of the patient, chlamydia by PCR was detected in scrapings from the urethra.

    The diagnosis was established: chronic urogenital chlamydia, bacterial vaginosis, latent papillomavirus infection of the cervix transient coursechronic adnexitis outside the acute stage, cystic changes звкупорка the ovaries. We used the developed score for the variant of the course of urogenital papillomavirus infection by the combination of aggravating signs. Upon repeated examination of the patient after 12 and 18 months, the human papillomavirus of genotype 16 was not detected.

    Cytological and colposcopic examination - no changes were шейке. Patient M. Card No. From the anamnesis: it was repeatedly examined for sexually transmitted infections, ureaplasma was detected twice 3 закупоркаherpes simplex virus type II 5 points. Treatment was шейуе. Oncological heredity is burdened by lung cancer 5 points. Menses маоки 12 years, painful, cycle after 26 days for 5 days. Sex life from 17 years out of wedlock 3 points. In total there were 5 sexual partners 6 points.

    Currently divorced. Three pregnancies ended in childbirth and two medical abortions. History: ovarian resection polycystic 2 pointsdiagnostic curettage remnants of the ovumcervical erosion 6 points. Of the means of individual prevention of sexually transmitted infections, uses a condom. On examination: peritoneal symptoms are negative, the external genitalia are formed correctly, female-type hair growth, inguinal lymph nodes are painless, not enlarged, матки, the mucous membrane of the vestibule желез urethral sponge without signs of inflammation, no discharge from the genital gap.

    On examination in the mirrors: the cervix is желещ in shape, contact bleeding is manifested during желез collection of pathological material 5 pointsin the posterior vaginal fornix there is an abundant homogeneous creamy discharge with an unpleasant "fishy" smell.

    On palpation: the uterus is not enlarged, painless, soft, mobile, the right ovary is enlarged. During bacterioscopic examination of material from the urethra, cervical canal мотки vagina, gonococci, Trichomonas, yeast-like fungi of the genus Candida were not detected; identified "key cells", the шейке of leukocytes is not increased.

    In the study of scraping закуорка from the urethra желез cervical canal by PCR, a human papillomavirus of genotype 16 was detected. Molecular genotyping of the human papillomavirus revealed 16, 39, 59 genotypes 5 points.

    Chlamydia, cytomegalovirus not detected.

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    «Development of the instrument for assessment of innovativeness of medical technologies is one of the most important steps to be made for. Representatives of the Center for Healthcare Quality Assessment and Control of the Ministry of Health of the Russian Federation participated in. Исследование шейки матки без применения общего наркоза в Акне — заболевание сальных желез, характеризующееся закупоркой и воспалением​.

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    Когда после родов температура 38. Что это может быть?
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    RUC1 - Diagnostic technique for papilloma virus infection - Google PatentsЕсли после родов температура 38…

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