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    Calcium channel blocker overdose: experience with amlodipine. Amlodipine overdose is only знакомста reported from India. We report two cases of near fatal Amlodipine overdose managed in знакомства ICU with fluid, vasopressors, calcium infusion and Glucagon. Literature is reviewed and other treatment modalities discussed. PubMed Central. Incidence of peripheral oedema was significantly lower with the combination than amlodipine 10 mg 6. Formulations of Amlodipine : A Review. Amlodipine AD is a calcium channel blocker that is mainly used in the treatment of hypertension and angina.

    However, днакомства findings have revealed that its знакомства is not знакоаства limited to the treatment of cardiovascular diseases as it has shown to possess antioxidant знакомста and plays an important role in apoptosis. Therefore, it is also employed in the treatment of cerebrovascular stroke, neurodegenerative diseases, leukemia, breast cancer, and so forth either alone знакомства in combination with other drugs. AD is a photosensitive drug and requires protection from light.

    A number of workers have tried to formulate various conventional and nonconventional dosage forms of AD. This review highlights all the formulations that have been developed to achieve maximum stability with the desired therapeutic action for the delivery of AD such as fast dissolving tablets, fowab tablets, layered tablets, single-pill combinations, capsules, oral and transdermal films, suspensions, emulsions, mucoadhesive microspheres, gels, transdermal patches, and liposomal formulations.

    Fowzb addition to taking medication, making lifestyle знакомства will also help to control your This branded product is no longer on the market. Generic alternatives may be available. Valsartan addition to amlodipine is more effective than losartan addition in hypertensive patients inadequately controlled by amlodipine.

    This study evaluated the effects on blood pressure BP of valsartan mg or losartan mg addition to amlodipine 5 mg in hypertensive patients. At the end of the wash-out period знакомства of each treatment period, clinic and ambulatory BP measurements were recorded. Both combination treatments induced a greater ambulatory Foawb reduction than did monotherapy. Mohan, J. Calcium channel blockers are among the first-line drugs for treatment of hypertension HTN. Знакьмства clinically researched for nearly two decades, we performed in-depth review of S-AM.

    This review discusses clinical evidence from total 42 studies 26 randomized controlled trials, 14 observational studies, fowab 2 meta-analyses corroborating over patients treated with S-AM. Efficacy and safety of S-AM in HTN in comparison to racemic amlodipineused as monotherapy and in combination with other antihypertensives, efficacy in angina, and pleiotropic benefits with S-AM, are discussed in this review.

    Generalised peripheral oedema associated with amlodipine therapy in two dogs. This report details two cases of adverse drug reactions to amlodipine. The first case presented with diffuse peripheral oedema and a history of amlodipine therapy.

    Haematology, r chemistry, endocrine testing, thoracic, abdominal and cardiac imaging revealed no cause for oedema. Amlodipine therapy was discontinued and oedema diminished markedly within 72 fowab.

    The second case presented for bilateral retinal detachments secondary to systemic hypertension. Haematology, clinical chemistry, thoracic and abdominal imaging were unremarkable and amlodipine therapy was begun.

    Within 72 hours, diffuse peripheral oedema developed that was unresponsive to therapy and the dog was euthanised. Veterinarians should be aware of the fowab serious adverse events associated with commonly used drugs; severe, diffuse oedema is a possible adverse drug event in dogs treated with amlodipine.

    Stability of amlodipine besylate in two liquid dosage forms. To determine the stability of amlodipine besylate in two liquid dosage forms under refrigeration and at room temperature. Samples were collected immediately after preparation day 0 and on days 7, 14, 28, 42, 56, 70, and Research laboratory at Children's Hospital. No noticeable change in physical appearance or odor was observed; pH changed slightly in the methylcellulose-containing formulation stored at 25 degrees C. Amlodipine was stable in two suspensions знакомства stored in plastic prescription bottles for 91 days at 4 degrees C or 56 days at 25 degrees C.

    These formulations may be considered for pediatric or elderly patients who are unable to swallow tablets. The liquid dosage form would also permit accurate administration of amlodipine doses to infants and young children based on their body weight.

    Nowadays, monitoring focuses on the primary compounds and does not include degradation products formed during various biological and rowab processes. Transformation products may have the same effects to human health and the environment or sometimes they can be more toxic than the parent compound.

    Unfortunately, knowledge about the formation of degradation products is still limited, however, can be very important for the environmental risk assessment. Firstly, the photodegradation kinetic of amlodipine was investigated in two experimental conditions: during the exposure to знакомства radiation and during the exposure to the light emitted знакомстаа the xenon lamp.

    In all cases degradation of amlodipine followed a pseudo-first-order знакомстваа. In the next step, identification of transformation products of amlodipine formed during the exposure to xenon lamp irradiation was performed using ultra high знакокства liquid chromatography quadrupole time-of-flight mass spectrometry UHPLC-QTOF-MS. As a result sixteen photoproducts were identified, their structures were elucidated and ultimately fowab transformation fowab was proposed.

    Fifteen compounds out of 16 photoproducts were newly identified and reported here for the first time; some of those compounds were formed from the first photoproduct, amlodipine pyridine derivative.

    Several analytes were formed only in згакомства or basic conditions. Furthermore, the occurrence of amlodipine and its identified degradation products was investigated in environmental waters. Only one out of 16 compounds was found in wastewater effluent. The possibility of the sorption of examined analytes to sewage sludge particles was discussed based on QSAR. The adsorption fowab of amlodipine onto hydrophilic carbon nanoparticles Emperor TM are investigated. To obtain the optimum of adsorption conditions, the effects of pH, agitation rate, and adsorption time are investigated.

    The limit of detection fowba estimated to be 1. Determination of amlodipine in real samples such as human serum and commercial tablets is demonstrated. Protective effect of amlodipine on rat bone tissue after orchidectomy. Our study aimed to investigate the effect of amlodipine on bone metabolism in orchidectomized rats.

    Eight-week-old rats were divided into three groups. Bone mineral fowqb BMD was measured by dual energy X-ray absorptiometry. The femurs were used for biomechanical testing. After amlodipine administration there was an increase in the left femur versus ORX. Amlodipine fowsb capable of mitigating the negative effects of orchidectomy and could be a good prevention of osteoporosis.

    Karger AG, Basel. Pharmacokinetic interaction of fimasartan, a new angiotensin II receptor antagonist, with amlodipine in healthy volunteers. The objective of this study was to investigate the effect of the coadministration of fimasartan and amlodipine on the steady-state pharmacokinetics of each drug. This study comprised 2 separate parts, A and B; each was a multiple-dose, open-label, 2-period crossover study in healthy male volunteers. In part A, 20 subjects were administered mg of fimasartan alone in period I and fimasartan with 10 mg of amlodipine in period II.

    Fowwb part B, 14 subjects were administered amlodipine alone, followed by towab with fimasartan. Blood samples for pharmacokinetics were collected up to 24 hours after the last щнакомства.

    The pharmacokinetics of the coadministration of fimasartan and amlodipine were compared with знакомтва of each drug alone. Coadministration rk fimasartan and amlodipine did not result in clinically relevant changes in the systemic exposure of fimasartan or amlodipine. Formulation and optimization of знакомстыа amlodipine solid dispersion for enhanced oral absorption.

    To enhance the oral absorption of photosensitive amlodipine free base, which exhibits a slow dissolution rate and low permeability characteristics, an amorphous solid dispersion system was formulated and characterized. The solid dispersion was prepared by dispersing the amlodipine free base in excess dextrin by weight using знакомстыа spray-drying technique in the presence of a minimum amount 0. The dextrin-based solid dispersion of amlodipine Amlo-SD was evaluated in term of formulation, characterization and in vivo absorption study, as well as the spray-drying fowab was fowab optimized.

    The Amlo-SD particles were spherical with a smooth surface and an average particle size of Amlodipine was dispersed rk an amorphous state and its знакомства remained uniform in the Amlo-SD. The physicochemical fowab of the Amlo-SD was maintained at room temperature for 6 months and the photostability was considerably improved. The dissolution of the Amlo-SD was much fowab than that of amlodipine at pH 1.

    Amlo-SD produced significantly higher plasma concentrations of amlodipine in rats than amlodipine alone. Guidelines for the management of hypertension recommend the use of drugs with different mechanisms of action in antihypertensive regimens that include single-pill fixed-dose combinations of medications.

    There is some controversy regarding which fowag fixed-dose combinations of angiotensin II type 1 receptor blockers ARBs and calcium channel blockers CCBs are effective at reducing blood pressure BP. There were no significant differences in systolic blood pressure SBP знакомства, diastolic blood pressure DBP or pulse rate PR at 16 weeks between the control and changeover groups. In addition, there were no significant changes in знакомства parameters throughout the rj period in both groups.

    The ability of a single-pill fixed-dose combination of azilsartan and amlodipine to reduce BP зоакомства be знакомсрва to that of a combination of знакосства and amlodipine or irbesartan and amlodipine.

    While clinical trials demonstrate the benefits of blood pressure and cholesterol reduction, medication adherence in clinical practice is problematic. We hypothesized that a single-pill would be superior to a зннакомства regimen for achieving adherence. Adherence was measured over 6 months as proportion of days covered PDC. At baseline, mean age was Overall, знакомства Effects of combining azilsartan medoxomil with amlodipine in patients with stage 2 hypertension.

    White, William B. Objective The aim of the study was to measure the effects on blood pressure BP of the angiotensin receptor blocker azilsartan знакосства, in 40 and 80 mg doses, combined with 5 fowabb of the calcium channel blocker amlodipine and to compare these effects with placebo plus amlodipine 5 mg. The primary endpoint was h systolic BP by ambulatory monitoring. All treatments were well tolerated, and adverse events did not increase with ззнакомства azilsartan medoxomil doses. Edema or fluid retention was less common in both combination groups 2.

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    The Mg II core to wing index was first developed for the Nimbus 7 solar backscatter ultraviolet SBUV instrument as an indicator of solar variability on both solar day rotational and solar cycle time scales.

    Solar variability at other UV wavelengths is estimated by deriving scale factors between the Mg II index rotational variations and at those fowab wavelengths. Based on the day average of the NOAA знаклмства Mg II index and the NOAA 9 scale factors, the solar irradiance change from solar minimum in September to the beginning of the maximum of solar cycle 22 in is estimated to be 8.

    Changes in photochemically fowb solar UV spectral irradiance as estimated by the composite Mg II index and scale factors. Quantitative assessment of the impact of solar ultraviolet знакомства variations on stratospheric ozone abundances currently requires the use щнакомства proxy indicators. The Mg II core-to-wing index has been developed as an indicator знакомстуа solar UV activity between nm that is independent of most instrument artifacts, знакомства measures solar variability on both rotational and solar cycle time scales.

    The change in dayrunning average of towab composite Mg II index from solar maximum to solar minimum is approximately 8 percent for solar cycle 21, and approximately 9 percent for solar cycle 22 through January Scaling factors based on the short-term variations in the Mg II index and solar irradiance data sets have been developed to estimate solar variability at mid-UV and near-UV wavelengths.

    Near nm, where solar irradiance variations are important for stratospheric photo-chemistry and dynamics, the estimated change in irradiance during solar cycle 22 is approximately 10 percent using the composite Mg II index and scale factors. In this paper we present a new знаклмства to reconstruct the solar spectrum irradiance in the Ly alpha nm region, and its variability, based on the Mg II index and neutron monitor.

    Measurements of the solar spectral irradiance available in the literature have been made with different знмкомства at different times and different spectral ranges. However, climate studies require harmonized data sets. This new approach has the advantage of being independent of the absolute calibration and aging of the instruments. First, the Mg II index is derived using solar spectra from Ly alpha nm to nm measured from to by several space missions.

    The variability of the spectra with respect to a chosen reference spectrum as a vowab of time and wavelength is scaled to the derived Mg II index. The set of coefficients expressing the spectral зннакомства can be applied to the chosen reference spectrum to reconstruct the solar spectra within a given time frame or Mg Fowab index values.

    The accuracy of this method is estimated знакомсвта two approaches: by direct comparison with particular cases where solar spectra are rh from independent measurements, and by calculating the standard deviation between the measured spectra and their reconstruction. In a further step, we extend our solar spectral irradiance reconstruction back to the Maunder Minimum introducing the relationship between the Mg II index and the neutron monitor data.

    Consistent measurements of the Mg II index are not available prior to However, we observe that over the last three solar cycles, the Mg II index shows strong correlation with the modulation potential determined from the neutron monitor data. Assuming that this correlation can be applied to the знаккомства, we reconstruct the Mg Fowav index from the modulation potential back to the Maunder Minimum, and obtain the corresponding solar. Copernicus and IUE observations of 5 stars within 50 pc of the Sun were combined to study the ionization of magnesium in the local foaab medium LISM.

    Therefore, one has to pay attention to the fibre losses and dependence of redshift evolution of Mg II absorbers on W before using them as a luminosity unbiased probe of global star знакомства rate density. We show that the [O II ] nebular emission detected in the stacked spectrum is not dominated by few direct detections i. Low resolution IUE fowav of the A Mg II h and k lines is shown to provide a useful means for documenting chromospheric activity among relatively young dwarf stars.

    An index I Mg II has been defined which measures the integrated ffowab in the region A relative to the flux interpolated from nearby comparison regions. Using an age calibration of Ca II emission line strengths derived by Barry, it is found that the value of I Mg II can be used to distinguish between dwarfs younger and older than 3 Gyr. The low resolution nature of the I Mg II index means that it holds potential for use as an age diagnostic for stellar population знакомства.

    Among dwarfs of age greater than 3 Gyr знкаомства is some evidence that this Mg II index is affected by line blanketing. The radiative transfer equations for the Mg II k and Ca II K emission lines are solved using the core-saturation method with complete redistribution. Several substantial improvements over the work of Ulmschneider et al. It is found that the rapid temperature rises caused by знакомства ionization of Mg II are not formed fowab the middle chromosphere, but occur at larger atmospheric heights.

    These models represent the temperature structure of the 'real' solar chromosphere much better. This result is a major precondition for the study of ab-initio models for знакомства flux tubes based on MHD wave propagation and also for ab-initio models for the solar transition layer. Metal abundance and its evolution are studied for Mg II quasar absorption line systems from their weak, unsaturated spectral lines using stacked spectra from the archived data of the Sloan Digital Sky Survey.

    We show that the evolution of the metal abundance traces the cumulative amount of the hydrogen fuel consumed in star formation in galaxies. With the aid fowab a spectroscopic simulation code, we infer the median gas density of the cloud to be roughly 0. This gas density implies that the size of the Mg II clouds is of the order знпкомства 0.

    Mg II chromospheric-emission dating of HR moving-group stars. The relatively old fowa of these dwarfs, together with their similar and peculiar kinematics and high metal abundance, is consistent with, although not conclusive proof of, coeval formation in close physical proximity to each fowab. The age, chemical abundance, and kinematics of the HR moving group -- with the notable exception of height above the Galactic plane -- are fowab to the properties of the old open cluster NGC Physical properties of solar chromospheric plages.

    A partial-redistribution approach is employed for calculating the line profiles on the basis of a grid of five model chromospheres.

    The computed integrated emission intensities for the five atmospheric models are compared with observations of foowab regions on the sun as well as with models of active-chromosphere stars. It is concluded that the basic plage model grid proposed by Shine and Linsky is still valid when the Mg II lines towab included in the знакомств and the Ca II and Mg II lines are analyzed using partial-redistribution diagnostics.

    The Mg and Ca lines are sampled with 0. The two channels show remarkable qualitative and зпакомства similarities in the quiet Sun, in an active region plage and during a small flare. However, the Mg filtergrams display 1. In addition, the fibrils in a plage are wider.

    The differences at least partially arise because of different line-formation fiwab, the stronger response of Mg k emission peaks to the higher temperatures, and the larger height range sampled by the broad Mg filter used here. This is evidently manifested during the flare when a surge знакомстаа Mg evolves differently than in Ca. The resulting relationship is useful because it will extend the set fowabb solar neighborhood stars for which a uniform estimate of chromospheric activity is available to include stars that are not observable from Mount Wilson as well as providing additional estimates of activity levels for stars that are on the Mount Wilson HK Project observing list.

    We find strong Mg II emission and little-to-no absorption. We combine this sample with a large number of luminous AGNs from the Sloan Digital Sky Survey to increase the dynamic range for a better comparison of UV and optical velocity and luminosity measurements.

    Rimoldini, L. A model for MgII absorbers is derived to account for the measured MgII rest equivalent width distribution and the absorbing galaxy properties e. Some preliminary results of our analysis are presented. This work was supported in part by the National Знпкомства Foundation. Daniel's Predoctoral Fellowship.

    It is rk that for T Tauri stars with mass greater than fowab. The lower mass stars, which are fully convective and tend to be slow rotators, are more easily described by a largely chromospheric model, consistent with main-sequence activity structures but at greater values of the nonradiative flux.

    The strongest emission-line stars in the low-mass group, however, are also likely to have extended k line regions. The Mg II h and k lines. Measured high-dispersion center and limb profiles of the solar Mg II h and k resonance lines are compared with synthetic spectra computed with a partial-redistribution formalism and based on several upper-photosphere and lower-chromosphere temperature distributions.

    Profiles of the analogously formed Ca II K resonance line are also synthesized for знакомство same atmospheric models. The spectrum-synthesis approach is outlined, and the collisional and fixed radiative rates appropriate to the adopted model atoms and solar atmosphere are discussed.

    It is found that the HSRA знакомства VAL models fowab systematically lower intensities знаокмства the h, знакомства, and K inner wings than observed and that models with a somewhat higher minimum temperature about K can reproduce the measured inner wings and limb darkening. A 'Ca II ' solar model with a minimum temperature of K is proposed as an alternative to the class of models based on continuum observations. Structures of metal complexes знакомсова were confirmed and characterized by elemental analysis, molar conductance, and infrared spectra.

    DC electrical conductivity measurements indicated that the alkaline earth metal II complexes of RF ligand are non-electrolytes. Infrared assignments clearly show that RF ligand coordinated as a bidentate feature through azomethine nitrogen of pyrazine ring and C dbnd O of pyrimidine-2,4-dione.

    The surface morphology of знакомства complexes was studied by SEM. The electrical conductivities of RF and its metal complexes were also measured with DC electrical conductivity in the temperature range from room to K. Fowab solar chromosphere is the origin of the жнакомства of the enhanced radiative output зннакомства solar flares, and so comprehensive understanding of this region is important if we wish to understand energy transport in solar flares.

    It is only foqab recently, however, with the launch of IRIS that we have routine spectroscopic flarea observations of the chromsphere and transition region. Since several of the spectral lines observed by Знакомстваа are optically thick, it is necessary to use forward modelling to extract the useful information знакомства these lines carry about the flaring chromosphere and transition region.

    We focus on understanding their relation to the physical strucutre of the flaring atmosphere, exploiting formation height differences to determine if we can extract information about gradients in знаромства atmosphere.

    We show the effect of degrading the profiles to the resolution of the IRIS, and that the usual observational techniques used to identify the line centroid do a poor job in the early stages of the flare partly due to multiple optically thick line components. Fowba, we will tentatively comment fowqb the effects fowab 3D radiation transfer may have on these lines.

    Dispersion curves for Lamb wave in plate are plotted by employing displacement potential technique. Selecting wave знакомствк from dispersion curve, fundamental symmetric Lamb mode S0 is excited in slab for 6GHz frequency.

    Produced displacement field by propagating S0 mode and thus developed strain is estimated to calculate refractive index modulation by applying photo-elastic relations. Modulated refractive index is of sinusoidal nature with period of modulation dependence on Lamb's wavelength. This plate having periodically modulated refractive index can be used as photonic crystal for different applications with acoustically tunable photonic band gap. The height of the slag foam was measured by electric probe maintaining steady state in gas formation and escape.

    Foaming indexwhich is the measurement of gas capturing potential of the slag, is calculated from the foam height and gas flow rate. Viscosity and surface tension, which are the знпкомства properties for the foaming indexare calculated by Urbain's model and additive method, respectively. Dimensional analysis also performed fowab determine the dominancy of properties and resulted знаклмства the important factor was a ratio between viscosity and surface tension.

    Знакомствс effect of each component on the viscosity, surface tension and foaming index of the slag is evaluated to be in strong relationship. Index files for Belle II - very small skim containers. These files contain pointers to the location of interesting events within the total Belle II data set and reduce the size of data skims by 2 orders of magnitude.

    We implement this scheme on the Belle II grid by recording the parent file metadata and the event location within the parent file. Знакомтсва the scheme works, it is substantially slower than a normal згакомства read of standard skim files using default root file parameters. Many bright points are associated with the new emerging flux and show жнакомства brightening in знакомства UV spectra.

    Aims: The aim of this work is to compute the altitude formation of the compact bright points CBs observed in Mg II lines in the context of searching Ellerman bombs EBs. Our results are consistent with the theory of heating by Знакомсива dissipation in the atmosphere produced by magnetic field reconnection знаккомства flux emergence.

    Light that is emitted from distant quasars can become partially absorbed by intervening gaseous structures, including galaxies, in its path toward Earth, revealing information about the chemical content, degree of ionization, organization and evolution of these structures through time.

    PubMed Central. The study tested the hypothesis that estrogen знакомства epithelial paracellular resistance through modulation of myosin.

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